The Chaperone - BeardManWalking

The Chaperone’s Secret

Publisher : Beyond The Page
Release Date : 2017-10-30
ISBN : 1946069426
Pages : 133 pages
Rating Book: 4.4/5 (946 users)

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Download or read book The Chaperone’s Secret written by Donna Lea Simpson and published by Beyond The Page. This book was released on 2017-10-30 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the author of An Eccentric Engagement comes a Regency romance celebrating the witty and romantic world that fans of Georgette Heyer have fallen in love with. “Simpson excels at imbuing her realistic characters with subtle depths!” —John Charles, American Library Association As chaperone to the Season’s most desirable young miss, Amy Corbett has two specific duties: to ensure that her charge’s reputation remain spotless, and to see her betrothed to an exceptional beau. Given that the coquettish Lady Rowena manages to maintain an air of propriety while being a flirt of the highest caliber, Amy knows her job should be easy—if only the calculating young aristocrat weren’t so set on toying with men’s hearts, including that of her latest prey, the debauched Lord Dante Pierson. Like other gentlemen of high standing and low tastes, Lord Pierson’s restless desire for excitement had driven him into a life of squalor and scandalous social blunders. Finding himself drunk and mud-spattered in a gutter one night, he spies an angelic apparition in a passing carriage and is overcome by a will to reform—surely such a woman could give him hope of rebirth. When he learns that the anonymous beauty is Lady Rowena, he vows to coax that flicker of warmth into a flame. As Rowena lures the unsuspecting Pierson ever closer to heartbreak, Amy realizes that for all the talk of his wastrel ways, he is actually a gentle and caring man to be championed and cherished. And in an unguarded moment, the unassuming Amy and downtrodden Lord Pierson will discover that they possess kindred souls—and will make a daring decision to follow their own true path to happiness and love . . . This book was originally published as Lord Pierson Reforms.

The Hsp70 Molecular Chaperone Machines

by Matthias P. Mayer

Publisher : Frontiers Media SA
Release Date : 2017-03-24
ISBN : 2889451259
Pages : 71 pages
Rating Book: 4.8/5 (889 users)

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Download or read book The Hsp70 Molecular Chaperone Machines written by Matthias P. Mayer and published by Frontiers Media SA. This book was released on 2017-03-24 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form HSPA1A (HSP70), its constitutive cytosolic cognate HSPA8 (Hsc70), its endoplasmic reticulum form HSPA5 (BiP), and its mitochondrial form HSPA9 (Mortalin), as well as the more distantly related HSPHs (HSP110s), make up 1-2 % of the total mass of proteins in human cells. They use the energy of ATP-hydrolysis to prevent and forcefully revert the process of protein misfolding and aggregation during and following various stresses, presumably by working as unfoldases to lift aberrant conformers out of kinetic traps. As such, HSP70s, in cooperation with their J-domain co-chaperones and nucleotide exchange factors (NEFs) and co-disaggregases, form an efficient network of cellular defenses against the accumulation of cytotoxic misfolded protein conformers, which may cause degenerative diseases such as Parkinson's and Alzheimer's disease, diabetes, and aging in general. In addition to their function in repair of stress-induced damage, HSP70s fulfill many housekeeping functions, including assisting the de novo folding and maturation of proteins, driving the translocation of protein precursors across narrow membrane pores into organelles, and by controlling the oligomeric state of key regulator protein complexes involved in signal transduction and vesicular trafficking. For reasons not well understood, HSP70s are also found on the surface of some animal cells, in particular cancer cells where they may serve as specific targets for cancer immunotherapy. Here, we gathered seven mini reviews, each presenting a complementary aspect of HSP70’s structure and function in bacteria and eukaryotes, under physiological and stressful conditions. These articles highlight how, the various members of this conserved family of molecular chaperones, assisted by their various J-domain and NEF cochaperones and co-disaggregases, harness ATP hydrolysis to perform a great diversity of life-sustaining cellular functions using a similar molecular mechanism.

Proteostasis and Chaperone Surveillance

by Laishram Rajendrakumar Singh

Publisher : Springer
Release Date : 2015-11-26
ISBN : 8132224671
Pages : 180 pages
Rating Book: 4.3/5 (132 users)

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Download or read book Proteostasis and Chaperone Surveillance written by Laishram Rajendrakumar Singh and published by Springer. This book was released on 2015-11-26 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure, as well as the inhibition of proteostatic failure using small molecule compounds. It examines advances in the modulation of proteopathies, providing a comprehensive source of key mechanistic insights on these diseases. As such, the book offers a valuable resource for beginners and more experienced investigators alike who are looking for detailed and reliable information on protein homeostasis, the diseases that can develop due to related imbalances and the essential role of molecular and chemical chaperones.

Transport of Molecules Across Microbial Membranes

by J. K. Broome-Smith

Publisher : Cambridge University Press
Release Date : 1999-10-14
ISBN : 9780521772709
Pages : 292 pages
Rating Book: 4.7/5 (772 users)

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Download or read book Transport of Molecules Across Microbial Membranes written by J. K. Broome-Smith and published by Cambridge University Press. This book was released on 1999-10-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date review of an important area in microbiology.

Replicating And Repairing The Genome: From Basic Mechanisms To Modern Genetic Technologies

by Kenneth N Kreuzer

Publisher : World Scientific
Release Date : 2020-03-16
ISBN : 9811215715
Pages : 440 pages
Rating Book: 4.1/5 (811 users)

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Download or read book Replicating And Repairing The Genome: From Basic Mechanisms To Modern Genetic Technologies written by Kenneth N Kreuzer and published by World Scientific. This book was released on 2020-03-16 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Replicating and Repairing the Genome provides a concise overview of the fields of DNA replication and repair. The book is particularly appropriate for graduate students and advanced undergraduates, and scientists entering the field or working in related fields. The breadth of information regarding DNA replication and repair is vast and often difficult to absorb, with terminology that differs between experimental systems and with complex interconnections of these processes with other cellular pathways. This book provides simple conceptual descriptions of replication and repair pathways using mostly generic protein names, laying out the logic for how the pathways function and highlighting fascinating aspects of the underlying biochemical mechanisms and biology. The book incorporates extensive and informative diagrams and figures, as well as descriptions of a number of carefully chosen experiments that had major influences in the field.The process of DNA replication is explained progressively by starting with the system of a simple bacterial virus that uses only a few proteins, followed by the well-understood bacterial (E coli) system, and then culminating with the more complex eukaryotic systems. In the second half of the book, individual chapters cover key areas of DNA repair — postreplication repair of mismatches and incorporated ribonucleotides, direct damage reversal, excision repair, and DNA break repair, as well as the related areas of DNA damage tolerance (including translesion DNA polymerases) and DNA damage responses. The book closes with chapters that describe the huge impact of DNA replication and repair on aspects of human health and on modern biotechnology.

GeNeDis 2016

by Panayiotis Vlamos

Publisher : Springer
Release Date : 2017-10-01
ISBN : 3319562460
Pages : 338 pages
Rating Book: 4.1/5 (319 users)

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Download or read book GeNeDis 2016 written by Panayiotis Vlamos and published by Springer. This book was released on 2017-10-01 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2nd World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2016), focuses on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and provides an international forum for the latest scientific discoveries, medical practices and care initiatives. Advanced information technologies are discussed concerning the various research, implementation and policy, as well as European and global issues in the funding of long-term care and medico-social policies regarding elderly people. This volume focuses on the sessions from the conference on computational biology and bioinformatics.

Epigenetic Drug Discovery

by Wolfgang Sippl

Publisher : John Wiley & Sons
Release Date : 2018-12-10
ISBN : 3527809287
Pages : 480 pages
Rating Book: 4.2/5 (527 users)

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Download or read book Epigenetic Drug Discovery written by Wolfgang Sippl and published by John Wiley & Sons. This book was released on 2018-12-10 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.

Microbial Biofilms

by Mahmoud Ghannoum

Publisher : John Wiley & Sons
Release Date : 2020-08-11
ISBN : 1555817467
Pages : 404 pages
Rating Book: 4.5/5 (555 users)

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Download or read book Microbial Biofilms written by Mahmoud Ghannoum and published by John Wiley & Sons. This book was released on 2020-08-11 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: An examination of the research and translational application to prevent and treat biofilm-associated diseases In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense. Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically, Microbial Biofilms provides state-of-the-art research in the field of bacterial and fungal biofilms detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms future areas of research and their translational and clinical applications Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.

The Galaxy

by William Conant Church

Publisher :
Release Date : 1877
ISBN :
Pages : 892 pages
Rating Book: 4.9/5 (39 users)

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Download or read book The Galaxy written by William Conant Church and published by . This book was released on 1877 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cellular Effects of Heavy Metals

by Gaspar Banfalvi

Publisher : Springer Science & Business Media
Release Date : 2011-03-02
ISBN : 9400704283
Pages : 348 pages
Rating Book: 4.0/5 (4 users)

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Download or read book Cellular Effects of Heavy Metals written by Gaspar Banfalvi and published by Springer Science & Business Media. This book was released on 2011-03-02 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term “heavy metals” is used as a group name of toxic metals and metalloids (semimetals) causing contaminations and ecotoxicity. In strict chemical sense the density of heavy metals is higher than 5 g/cm3. From biological point of view as microelements they can be divided into two major groups. a. For their physiological function organisms and cells require essential microelements such as iron, chromium (III), cobalt, copper, manganese, molidenium, zinc. b. The other group of heavy metals is toxic to the health or environment. Of highest concern are the emissions of As, Cd, Co, Cu, Hg, Mn, Ni, Pb, Sn, Tl. The toxicity of heavy metals is well known at organizational level, while less attention has been paid to their cellular effects. This book describes the toxicity of heavy metals on microorganisms, yeast, plant and animal cells. Other chapters of the book deal with their genotoxic, mutagenic and carcinogenic effects. The toxicity of several metals touch upon the aspects of environmental hazard, ecosystems and human health. Among the cellular responses of heavy metals irregularities in cellular mechanisms such as gene expression, protein folding, stress signaling pathways are among the most important ones. The final chapters deal with biosensors and removal of heavy metals. As everybody is eating, drinking and exposed to heavy metals on a daily basis, the spirit of the book will attract a wide audience.

The Cell as a Machine

by Michael Sheetz

Publisher : Cambridge University Press
Release Date : 2018-01-11
ISBN : 1108548016
Pages : 438 pages
Rating Book: 4.0/5 (18 users)

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Download or read book The Cell as a Machine written by Michael Sheetz and published by Cambridge University Press. This book was released on 2018-01-11 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique introductory text explains cell functions using the engineering principles of robust devices. Adopting a process-based approach to understanding cell and tissue biology, it describes the molecular and mechanical features that enable the cell to be robust in operating its various components, and explores the ways in which molecular modules respond to environmental signals to execute complex functions. The design and operation of a variety of complex functions are covered, including engineering lipid bilayers to provide fluid boundaries and mechanical controls, adjusting cell shape and forces with dynamic filament networks, and DNA packaging for information retrieval and propagation. Numerous problems, case studies and application examples help readers connect theory with practice, and solutions for instructors and videos of lectures accompany the book online. Assuming only basic mathematical knowledge, this is an invaluable resource for graduate and senior undergraduate students taking single-semester courses in cell mechanics, biophysics and cell biology.

International Convention Against Doping in Sport

Publisher :
Release Date : 2008
ISBN :
Pages : 198 pages
Rating Book: 4.O/5 ( users)

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Download or read book International Convention Against Doping in Sport written by and published by . This book was released on 2008 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Policing Sexual Assault

by Jeanne Gregory

Publisher : Psychology Press
Release Date : 1999
ISBN : 0415163889
Pages : 253 pages
Rating Book: 4.1/5 (415 users)

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Download or read book Policing Sexual Assault written by Jeanne Gregory and published by Psychology Press. This book was released on 1999 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study uses case studies and interviews to find out why, when the number of rape cases has almost trebled since 1985, the proportion of cases resulting in a conviction has fallen.

Functional Relevance of Tetraspanins in the Immune System

by Carlos Cabañas

Publisher : Frontiers Media SA
Release Date : 2019-10-09
ISBN : 2889630609
Pages : 144 pages
Rating Book: 4.8/5 (889 users)

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Download or read book Functional Relevance of Tetraspanins in the Immune System written by Carlos Cabañas and published by Frontiers Media SA. This book was released on 2019-10-09 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tetraspanins are small (20-50 kDa) integral membrane proteins with four transmembrane domains that have an intrinsic propensity to associate with other membrane proteins and lipids giving rise to the formation of specific tetraspanin-enriched microdomains (TEMs), also referred to as “The tetraspanin web”. In mammals, the tetraspanin family comprises of 33 different members, with the majority of the members being abundantly expressed in almost all cell types, including leukocytes which are responsible for innate and adaptive immunity as well as in other cells that play pivotal roles in immune responses, such as endothelial or stromal cells. Therefore, through the wide range of specific molecular interactions in which they are engaged, tetraspanins influence many processes of up-most relevance in the development, physiology and pathology of the immune system, including the control of immune cell morphology, signaling, adhesion, migration, invasion, fusion, infections and cancer.

Toxicity and Autophagy in Neurodegenerative Disorders

by José M. Fuentes

Publisher : Springer
Release Date : 2015-05-04
ISBN : 3319139398
Pages : 268 pages
Rating Book: 4.1/5 (319 users)

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Download or read book Toxicity and Autophagy in Neurodegenerative Disorders written by José M. Fuentes and published by Springer. This book was released on 2015-05-04 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.

Life

Publisher :
Release Date : 1897
ISBN :
Pages : 898 pages
Rating Book: 4.2/5 (32 users)

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Download or read book Life written by and published by . This book was released on 1897 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Targeted Drug Delivery

by Yogeshwar Bachhav

Publisher : John Wiley & Sons
Release Date : 2022-10-24
ISBN : 3527827870
Pages : 468 pages
Rating Book: 4.2/5 (527 users)

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Download or read book Targeted Drug Delivery written by Yogeshwar Bachhav and published by John Wiley & Sons. This book was released on 2022-10-24 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Drug Delivery Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field. The following key topics are addressed: Antibody conjugates, prodrugs, and suicide gene therapeutics Protac technology for selectively degrading target proteins Delivery of nucleic acid drugs Novel drug carriers, such as liposomes, vesicles, and nanoparticles Unmet medical needs for which there is a large market potential, such as viral infections and cancer For chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.